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What method is used to calculate power in a clinical trial?

  1. The number of adverse events

  2. The dropout rate

  3. Using effect size and variability

  4. The number of sites involved in the trial

The correct answer is: Using effect size and variability

Power is a statistical measure used to determine the likelihood of detecting a true treatment effect in a clinical trial. It is calculated by taking into account factors such as the desired level of significance, sample size, and effect size. In order to accurately determine power, it is necessary to know the effect size and variability of the treatment being tested. Therefore, options A, B, and D are incorrect as they do not consider effect size and variability, which are essential components in calculating power for a clinical trial.