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What should investigators do to prevent accidental or premature destruction of essential study documents?

  1. Organize documents into sections

  2. Store documents in a secure location with limited access

  3. Prevent accidental/premature destruction

  4. All of the above

The correct answer is: Prevent accidental/premature destruction

Investigators should definitely take preventive measures to avoid accidental or premature destruction of essential study documents. While organizing documents into sections (option A) and storing them in a secure location with limited access (option B) may help with organization and security, they do not specifically address the issue of preventing accidental or premature destruction. Option D may seem like a logical choice, but it is important to note that not all essential study documents will have the same level of security or organization needs. Therefore, option C is the most appropriate and specific answer to this question.