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When should unused supplies of IP be returned to the sponsor or destroyed?

  1. After every study visit

  2. At the end of each month

  3. Should investigation be terminated, suspended or completed

  4. Only if the IP has expired

The correct answer is: Should investigation be terminated, suspended or completed

It is important to return or destroy any unused supplies of IP (investigational product) when clinical investigation is terminated, suspended, or completed. Options A, B, and D are incorrect because they do not account for other situations in which the investigation may end before completion, such as a suspension or early termination. By choosing option C, you ensure that no unused IP is left unaccounted for, which could have implications for patient safety and follow-up of study participants. Option A is too frequent and may result in unnecessary waste of IP, while options B and D are not comprehensive enough.