SOCRA CCRP Practice Exam

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Which method is NOT used to reduce bias in clinical trials?

Randomization
Blinding
Open label
Using a placebo control group

The correct answer is: Open label

Open label is not a method used to reduce bias in clinical trials. In fact, it can actually introduce bias as participants and researchers are aware of which treatment they are receiving. This can lead to a placebo effect or researcher bias. Randomization helps to evenly distribute potential confounding factors among the treatment groups, reducing bias. Blinding ensures that participants and/or researchers do not know which treatment is being received, reducing bias. Using a placebo control group helps to account for the placebo effect and reduce bias.