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Which of the following is an essential document only kept by the investigator before a trial?

  1. Laboratory certification

  2. Advertisements

  3. Trial monitoring report

  4. Insurance (if applicable)

The correct answer is: Advertisements

Advertisements are the only option listed here that is specifically used by the investigator before a trial. Laboratory certification may be important for the overall research process, but it is not limited to just the investigator and may not be considered essential. Trial monitoring reports are also crucial for a successful trial, but they are not specific to just the investigator and may involve other team members. Insurance, if applicable, may also be important for the overall research process, but again, it is not limited to just the investigator and may not be considered essential. Therefore, the answer is B, as it is the only option that is an essential document specifically kept by the investigator before a trial.